Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 5/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426729 | 0.88 | TP53 (0.39) | SHMT1SHMT2LMNATP53MAPT | |
| SCHEMBL1655299 | 0.86 | ATM (0.46) | LMNATP53MAPT | |
| SCHEMBL7423907 | 0.85 | SHMT1 (0.56) | SHMT1SHMT2MAPTTLR7 | |
| SCHEMBL7425245 | 0.85 | HSD17B10 (0.39) | SHMT1SHMT2LMNATP53MAPT | |
| SCHEMBL7424356 | 0.83 | HDAC1 (0.36) | SHMT1SHMT2LMNAL3MBTL1MAPT | |
| SCHEMBL7426438 | 0.81 | L3MBTL1 (0.34) | LMNAL3MBTL1MAPTGRNSORT1 | |
| SCHEMBL7423853 | 0.80 | PPARA (0.35) | GRNSORT1 | |
| SCHEMBL7417819 | 0.80 | HDAC1 (0.34) | SHMT1SHMT2MAPTGRNSORT1 | |
| SCHEMBL7382337 | 0.79 | MAPT (0.41) | LMNAMAPT | |
| SCHEMBL7420766 | 0.79 | ALDH1A1 (0.47) | SHMT1SHMT2LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |