Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | GRN | P28799 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.32 |
| ▸ | ACE | P12821 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417819 | 0.93 | HDAC1 (0.34) | HDAC1HDAC6GRNSORT1SHMT1 | |
| SCHEMBL7426906 | 0.89 | HDAC1 (0.37) | HDAC1HDAC6KMT2ABCHE | |
| SCHEMBL7422281 | 0.83 | SHMT1 (0.39) | GRNSORT1SHMT1SHMT2LMNA | |
| SCHEMBL7423323 | 0.81 | BCHE (0.33) | HDAC1HDAC6KMT2ABCHE | |
| SCHEMBL7421104 | 0.81 | GRN (0.32) | GRNSORT1ACE2ACE | |
| SCHEMBL7419020 | 0.80 | GRN (0.38) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7425812 | 0.80 | GRN (0.33) | GRNSORT1ACE2ACE | |
| SCHEMBL7426438 | 0.79 | L3MBTL1 (0.34) | HDAC1HDAC6GRNSORT1ALDH1A1 | |
| SCHEMBL7382337 | 0.78 | MAPT (0.41) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL7423907 | 0.78 | SHMT1 (0.56) | SHMT1SHMT2RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |