Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533987 | 0.91 | MMP2 (0.42) | MMP2MMP9ADAMTS5PPARGPPARA | |
| SCHEMBL5033291 | 0.79 | ADAMTS5 (0.43) | MMP2MMP9ADAMTS5RORCPSEN1 | |
| SCHEMBL5033274 | 0.69 | ADAMTS5 (0.44) | MMP2MMP9ADAMTS5RORCPSEN1 | |
| SCHEMBL7674822 | 0.69 | ADAMTS5 (0.49) | MMP2MMP9ADAMTS5PPARGPPARA | |
| SCHEMBL7674815 | 0.69 | ADAMTS5 (0.49) | MMP2MMP9ADAMTS5PPARGPPARA | |
| SCHEMBL5033295 | 0.62 | ADAMTS5 (0.43) | MMP2MMP9ADAMTS5RORCMEN1 | |
| SCHEMBL10281161 | 0.61 | ALDH1A1 (0.55) | ADAMTS5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5033278 | 0.60 | ADAMTS5 (0.42) | MMP2MMP9ADAMTS5RORCMEN1 | |
| SCHEMBL15705806 | 0.57 | POLB (0.60) | ADAMTS5ADRB2KMT2A | |
| SCHEMBL15705731 | 0.57 | GAA (0.54) | ADRB2ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053226-A1 | SULFONYLAMINO DERIVATIVES WHICH INHIBIT MATRIX-DEGRADING METALLOPROTEINASES | Novartis AG (CH) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999042443-A1 | SULFONYLAMINO DERIVATIVES WHICH INHIBIT MATRIX-DEGRADING METALLOPROTEINASES | NOVARTIS AG (CH) | 1999-08-26 | — | — | WO | disclosed |