Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.49 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674815 | 1.00 | ADAMTS5 (0.49) | ADAMTS5MMP2MMP9MMEL1MMP1 | |
| SCHEMBL7533987 | 0.69 | MMP2 (0.42) | ADAMTS5MMP2MMP9PPARGPPARA | |
| SCHEMBL5033274 | 0.69 | ADAMTS5 (0.44) | ADAMTS5MMP2MMP9MMP1MMP3 | |
| SCHEMBL7303089 | 0.69 | KEAP1 (0.35) | MMP9MMP3MMP13PPARGPPARA | |
| SCHEMBL7424410 | 0.69 | MMP2 (0.42) | ADAMTS5MMP2MMP9MMP1MMP3 | |
| SCHEMBL5033291 | 0.68 | ADAMTS5 (0.43) | ADAMTS5MMP2MMP9MMP1MMP3 | |
| SCHEMBL31346619 | 0.68 | PPARA (0.45) | ADAMTS5PPARGPPARA | |
| SCHEMBL7738074 | 0.66 | L3MBTL1 (0.53) | POLB | |
| SCHEMBL7738077 | 0.66 | L3MBTL1 (0.53) | POLB | |
| SCHEMBL15393111 | 0.65 | POLB (0.42) | POLBPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |