Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 2/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764806 | 0.72 | SLC15A1 (0.44) | SLC15A1L3MBTL1RAB9ACASP6NPC1 | |
| SCHEMBL8764753 | 0.71 | CASP1 (0.43) | KMT2AALDH1A1CASP3MAPTMEN1 | |
| SCHEMBL5583677 | 0.70 | FEN1 (0.58) | KMT2AAKR1B1FEN1ALDH1A1KDM4E | |
| SCHEMBL12946377 | 0.70 | CASP3 (0.49) | KMT2AALDH1A1CASP3TXNRD1TDP1 | |
| SCHEMBL11230817 | 0.69 | KMT2A (0.46) | KMT2AAKR1B1FEN1ALDH1A1TXNRD1 | |
| SCHEMBL9245419 | 0.69 | CA12 (0.66) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL21866492 | 0.69 | ALDH1A1 (0.48) | KMT2AFEN1ALDH1A1KDM4ETXNRD1 | |
| SCHEMBL6801086 | 0.67 | ALDH1A1 (0.63) | KMT2AAKR1B1FEN1ALDH1A1CASP3 | |
| SCHEMBL18321223 | 0.66 | HCAR2 (0.49) | KMT2AALDH1A1SMN1; SMN2MAPTPTK2B | |
| SCHEMBL5703139 | 0.65 | ALDH1A1 (0.58) | KMT2AAKR1B1FEN1ALDH1A1TXNRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091930-A1 | C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals, Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001666-A1 | C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |