Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.41 |
| ▸ | YAP1 | P46937 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041703 | 0.85 | CTSD (0.49) | RENITGB3ITGA2B | |
| SCHEMBL7331235 | 0.85 | BCL2 (0.55) | RENBCL2PTPN1KLK5YAP1 | |
| SCHEMBL7422374 | 0.84 | BCL2 (0.49) | RENBCL2PTPN1KLK5 | |
| SCHEMBL8945503 | 0.84 | REN (0.49) | RENBCL2PTPN1KLK5YAP1 | |
| SCHEMBL8093075 | 0.84 | PPARA (0.48) | RENBCL2PTPN1KLK5YAP1 | |
| SCHEMBL7421310 | 0.84 | REN (0.49) | RENBCL2PTPN1KLK5YAP1 | |
| SCHEMBL7425726 | 0.83 | LTA4H (0.51) | RENITGB3ITGA2B | |
| SCHEMBL8945512 | 0.82 | REN (0.47) | RENBCL2PTPN1KLK5YAP1 | |
| SCHEMBL8945614 | 0.82 | REN (0.47) | RENBCL2PTPN1KLK5YAP1 | |
| SCHEMBL7417399 | 0.82 | REN (0.47) | RENBCL2PTPN1KLK5YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707564-B1 | DIFLUORO STATONE ANALOGS | MERRELL PHARMA INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-6114380-A | ANTIVIRAL AGENT; ADMINISTERING TO TREAT HIV INFECTION; N-(4-(N-BENZYLOXYCARBONYL-L-VALYL)AMINO-2,2-DIFLUORO-1,3-DIOXO-5-(4-(2-N -MORPHOLYL)ETHYLOXY)PHENYL-PENTYL)-O-((2-PYRIDYL)METHYL)-D-VALINOL, FOR EXAMPLE | MERRELL PHARMACEUTICALS INC. (US) | 2000-09-05 | — | — | US | disclosed |
| WO-1995001958-A1 | DIFLUORO STATONE ANALOGS | MERRELL PHARMACEUTICALS INC. (US) | 1995-01-19 | — | — | WO | disclosed |