Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310156 | 0.78 | GABRA1 (0.47) | — | |
| SCHEMBL7432943 | 0.76 | L3MBTL1 (0.40) | SLC6A2SLC6A4SLC6A3MAOASIGMAR1 | |
| SCHEMBL7426926 | 0.76 | SIGMAR1 (0.38) | KCNH2LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7425837 | 0.76 | KCNH2 (0.44) | KCNH2MAOBKDM4ESMN1; SMN2PTPRC | |
| SCHEMBL7430406 | 0.72 | VCP (0.47) | LMNAKDM4ESMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL7428890 | 0.72 | GABRA1 (0.37) | — | |
| SCHEMBL920619 | 0.72 | SLC6A2 (0.46) | KCNH2MAOBKDM4ESMN1; SMN2PTPRC | |
| SCHEMBL7428726 | 0.70 | GABRA1 (0.35) | — | |
| SCHEMBL931875 | 0.70 | PTPRC (0.59) | KCNH2MAOBLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8046767 | 0.69 | ADORA3 (0.36) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212306-A2 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019797-A2 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |