Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | GPR4 | P46093 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498980 | 0.86 | GPR84 (0.46) | TACR1GPR4KCNH2SLC6A4P2RX7 | |
| SCHEMBL5500050 | 0.85 | KCNH2 (0.43) | TACR1GPR4KCNH2OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL7983042 | 0.84 | KCNH2 (0.42) | TACR1GPR4KCNH2OPRM1OPRK1 | |
| SCHEMBL5502520 | 0.82 | KCNH2 (0.41) | TACR1GPR4KCNH2SOS1SLC6A4 | |
| SCHEMBL5500263 | 0.79 | KCNH2 (0.41) | TACR1GPR4KCNH2SLC6A4OPRM1 | |
| SCHEMBL5499921 | 0.78 | IDO1 (0.43) | SLC6A4P2RX7HTR1ADRD2DRD4 | |
| SCHEMBL7498985 | 0.78 | GPR4 (0.45) | TACR1GPR4KCNH2SLC6A4HTR1A | |
| SCHEMBL5502309 | 0.77 | KCNH2 (0.38) | TACR1GPR4KCNH2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL7983376 | 0.76 | GPR4 (0.44) | TACR1GPR4KCNH2SLC6A4HTR1A | |
| SCHEMBL5495685 | 0.76 | DPP4 (0.39) | GPR4KCNH2DRD2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240143-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. Carlsson Research AB (SE) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001046146-A1 | NEW MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2001-06-28 | — | — | WO | disclosed |