SCHEMBL7429208

SCHEMBL7429208

COC(=O)c1ncoc1CCNC(=O)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.52
MAPT P10636 2/20 0.52
HTT P42858 1/20 0.50
LMNA P02545 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
TGM2 P21980 1/20 0.46
KEAP1 Q14145 2/20 0.45
NFE2L2 Q16236 2/20 0.45
ATM Q13315 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7443335 0.91 MAPT (0.53) L3MBTL1MAPTHTTLMNASMN1; SMN2
SCHEMBL7432590 0.90 HTT (0.53) L3MBTL1MAPTHTTLMNASMN1; SMN2
SCHEMBL7435982 0.89 MAPT (0.52) L3MBTL1MAPTHTTLMNASMN1; SMN2
SCHEMBL6656904 0.81 MMP2 (0.52) LMNASMN1; SMN2GSK3B
SCHEMBL12203721 0.78 L3MBTL1 (0.49) L3MBTL1MAPTHTTLMNA
SCHEMBL11317135 0.78 PTGIR (0.48) SMN1; SMN2GSK3B
SCHEMBL7430347 0.77 L3MBTL1 (0.55) L3MBTL1MAPTHTTLMNASMN1; SMN2
SCHEMBL19578472 0.76 L3MBTL1 (0.49) L3MBTL1MAPTHTTLMNASMN1; SMN2
SCHEMBL22048857 0.76 LTA4H (0.49) L3MBTL1MAPTLMNASMN1; SMN2
Bromide SCHEMBL7342894 0.75 LMNA (0.44) L3MBTL1MAPTHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5312826-A Dicarboxylic acids with hypotensive agents and cardiovascular disorders TANABE SEIYAKU CO., LTD. (JP) 1994-05-17 US disclosed
EP-0519738-A1 Dicarboxylic acid derivatives and process for preparation thereof TANABE SEIYAKU CO., LTD. (JP) 1992-12-23 EP disclosed