Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | CFD | P00746 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427800 | 0.90 | LOXL2 (0.49) | LOXL2CFDCA1CA2L3MBTL1 | |
| SCHEMBL6370932 | 0.88 | CFD (0.53) | LOXL2AKR1C3CFDCA1CA2 | |
| SCHEMBL27594322 | 0.81 | LOXL2 (0.65) | LOXL2CFDL3MBTL1 | |
| SCHEMBL2900640 | 0.80 | ATM (0.63) | LOXL2CFDCA1CA2L3MBTL1 | |
| SCHEMBL11277128 | 0.79 | AKR1C3 (0.57) | AKR1C3 | |
| SCHEMBL10586175 | 0.78 | AKR1C3 (0.75) | AKR1C3L3MBTL1RAB9A | |
| SCHEMBL4629361 | 0.76 | ITGB3 (0.64) | LOXL2AKR1C3BLM | |
| SCHEMBL340537 | 0.76 | AKR1C3 (0.55) | AKR1C3CA1CA2CA12CA4 | |
| SCHEMBL7438758 | 0.76 | BRD4 (0.44) | AKR1C3HDAC8HDAC6 | |
| SCHEMBL7786090 | 0.75 | TP53 (0.55) | L3MBTL1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240154-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001044226-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |