Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.54 |
| ▸ | NCF1 | P14598 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11314258 | 0.98 | PTGER4 (0.53) | PTGER4NCF1MAPTALDH1A1KCNH3 | |
| SCHEMBL18394468 | 0.90 | PTGER4 (0.46) | PTGER4NCF1MAPTALDH1A1KCNH3 | |
| SCHEMBL7745287 | 0.89 | PTGER4 (0.51) | PTGER4NCF1MAPTALDH1A1KCNH3 | |
| SCHEMBL1421397 | 0.87 | PTGER4 (0.47) | PTGER4NCF1MAPTALDH1A1KCNH3 | |
| SCHEMBL7734442 | 0.86 | NCF1 (0.56) | PTGER4NCF1MAPTALDH1A1KCNH3 | |
| SCHEMBL2547601 | 0.84 | MAPT (0.63) | PTGER4MAPTALDH1A1GAAHTT | |
| SCHEMBL8720377 | 0.82 | HDAC3 (0.41) | PTGER4NCF1MAPTALDH1A1KDM4E | |
| SCHEMBL10498572 | 0.81 | PTGER4 (0.40) | PTGER4NCF1MAPTALDH1A1UTS2R | |
| SCHEMBL6201094 | 0.81 | MAPT (0.52) | MAPTALDH1A1KDM4EGAAHTT | |
| SCHEMBL20797652 | 0.80 | NCF1 (0.39) | PTGER4NCF1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007026312-A1 | 1,3-DIAMINOBENZENE DERIVATIVES AND COLORANTS COMPRISING THESE COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 2007-03-08 | — | — | WO | claimed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| WO-2021263079-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
| WO-2021263079-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-03-21 | — | — | US | disclosed |
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |
| US-20170253565-A1 | OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS | 2017-09-07 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| WO-2011123609-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011123609-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-10-06 | — | — | WO | disclosed |
| US-6506738-B1 | Treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection. | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-14 | — | — | US | disclosed |
| US-20020164741-A1 | Non-aqueous, liquid, enzyme-containing compositions | NOVOZYMES A/S (DK) | 2002-11-07 | — | — | US | disclosed |
| WO-2002026228-A1 | BENZIMIDAZOLONE ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |
| US-5686449-A | 1,5-benzodiazepines useful as gastrinor CCK-antagonists | GLAXO WELLCOME S.P.A. (IT) | 1997-11-11 | — | — | US | disclosed |
| US-4408072-A | Amido methoxyethylamines | AMERICAN CYANAMID COMPANY (US) | 1983-10-04 | — | — | US | disclosed |
| US-4314079-A | Novel methoxyethylamine | AMERICAN CYANAMID COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-3981677-A | Oxidative hair dye compositions containing N-substituted o-phenylenediamines and method for their use | CLAIROL INCORPORATED (US) | 1976-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | PTGER4 3400/4885NCF1 766/4885MAPT 3694/4885 |
| US-20020164741-A1 | Non-aqueous, liquid, enzyme-containing compositions | CNDP2, NOTUM, BCHE | PTGER4 3211/4885NCF1 1124/4885MAPT 2583/4885 |
| US-20170253565-A1 | OPIOID AGONISTS AND USES THEREOF | OPRM1, OPRK1, OPRD1 | PTGER4 249/4885NCF1 3630/4885MAPT 914/4885 |
| US-10590088-B2 | 4-(benzimidazol-2-ylamino)benzamide derivatives and methods of synthesis thereof | MCL1, BRDT, BOD1L1 | PTGER4 3104/4885NCF1 1839/4885MAPT 4683/4885 |
| US-20190084940-A1 | BENZAMIDE DERIVATIVES | BRDT, BRD3, BRD2 | PTGER4 4278/4885NCF1 1645/4885MAPT 4124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.