Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7430214 | 1.00 | FDPS (0.52) | FDPSSIGMAR1ACKR3TMEM97ALDH1A1 | |
| SCHEMBL7440692 | 0.89 | SIGMAR1 (0.62) | FDPSSIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7433683 | 0.84 | SIGMAR1 (0.65) | FDPSSIGMAR1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7439090 | 0.83 | SIGMAR1 (0.63) | FDPSSIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7441248 | 0.80 | NPC1 (0.59) | FDPSSIGMAR1TMEM97ALDH1A1MEN1 | |
| SCHEMBL7435436 | 0.80 | SIGMAR1 (0.54) | FDPSSIGMAR1ALDH1A1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7431292 | 0.78 | SIGMAR1 (0.53) | FDPSSIGMAR1ALDH1A1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7440012 | 0.78 | SIGMAR1 (0.53) | FDPSSIGMAR1TMEM97SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7425639 | 0.78 | NPC1 (0.57) | FDPSSIGMAR1TMEM97ALDH1A1MEN1 | |
| SCHEMBL7441263 | 0.78 | LTA4H (0.48) | FDPSSIGMAR1ACKR3TMEM97ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559569-A1 | Central nervous system antiischemic agents | Bristol-Myers Squibb Company (US) | 1993-09-08 | — | — | EP | disclosed |