Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.52 |
| ▸ | MMP9 | P14780 | 12/20 | 0.52 |
| ▸ | MMP14 | P50281 | 9/20 | 0.52 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP1 | P03956 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22090368 | 0.75 | LMNA (0.48) | — | |
| SCHEMBL7430251 | 0.75 | MMP2 (0.50) | MMP2MMP9MMP14MMP3MMP1 | |
| SCHEMBL7916925 | 0.75 | MMP2 (0.50) | MMP2MMP9MMP14MMP3MMP1 | |
| SCHEMBL56831 | 0.74 | MMP1 (0.51) | MMP2MMP9MMP14MMP3MMP1 | |
| SCHEMBL7924914 | 0.74 | CRBN (0.47) | MMP2MMP9MMP14MMP1MMP8 | |
| SCHEMBL20959508 | 0.71 | EPHX2 (0.50) | — | |
| SCHEMBL21820745 | 0.69 | CRBN (0.53) | MMP2MMP9MMP14 | |
| SCHEMBL27543888 | 0.67 | BCL2L1 (0.51) | MMP2MMP9MMP14MMP3MMP1 | |
| SCHEMBL2986117 | 0.67 | CCR2 (0.62) | — | |
| SCHEMBL4613043 | 0.67 | CTSK (0.77) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | claimed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | claimed |
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | disclosed |