Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.35 |
| ▸ | UBE2M | P61081 | 6/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618103 | 0.81 | LMNA (0.31) | SMN1; SMN2DCUN1D1UBE2MHPGD | |
| SCHEMBL7538627 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2GAAMAPTNPSR1 | |
| SCHEMBL6770905 | 0.79 | GHSR (0.38) | SLC6A2SLC6A4GHSRCTSD | |
| SCHEMBL4767101 | 0.78 | CTSD (0.37) | SLC6A2SLC6A4KMT2AMEN1GHSR | |
| SCHEMBL7541555 | 0.76 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4766714 | 0.75 | GHSR (0.37) | SLC6A2SLC6A4GHSRCTSDHPGD | |
| SCHEMBL4936544 | 0.75 | GHSR (0.37) | SLC6A2SLC6A4GHSRCTSDHPGD | |
| SCHEMBL7563297 | 0.73 | PSEN1 (0.37) | ALDH1A1SMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL6633602 | 0.73 | SLC6A2 (0.40) | ALDH1A1SMN1; SMN2SLC6A2SLC6A4GAA | |
| SCHEMBL6630511 | 0.71 | GRN (0.48) | SLC6A2SLC6A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |