Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428124 | 0.86 | CTSD (0.46) | CTSDHPGDALDH1A1HTTCLCN2 | |
| SCHEMBL431 | 0.84 | CTSD (0.63) | CTSDHPGDALDH1A1HTTHSD17B10 | |
| SCHEMBL29392137 | 0.84 | CTSD (0.63) | CTSDHPGDALDH1A1HTTHSD17B10 | |
| SCHEMBL1957953 | 0.83 | SMN1; SMN2 (0.56) | CTSDHPGDALDH1A1HTTKDM4E | |
| SCHEMBL536179 | 0.83 | HTT (0.62) | HPGDALDH1A1HTTCLCN2KDM4E | |
| SCHEMBL29688494 | 0.82 | ALDH1A1 (0.58) | HPGDALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL993303 | 0.82 | ALDH1A1 (0.58) | HPGDALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL527995 | 0.81 | PARP1 (0.56) | CTSDHPGDALDH1A1HTTKDM4E | |
| SCHEMBL9634001 | 0.81 | HTT (0.61) | HPGDALDH1A1HTTCLCN2KDM4E | |
| SCHEMBL30285248 | 0.81 | SLC6A3 (0.60) | CTSDHPGDALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |
| US-4710513-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1987-12-01 | — | — | US | disclosed |
| US-4567289-A | ANTICHOLESTEROL ANTILIPEMIC | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4459422-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1984-07-10 | — | — | US | disclosed |
| US-4375475-A | ANTICHOLESTEROL AGENTS | MERCK & CO., INC. (US) | 1983-03-01 | — | — | US | disclosed |
| EP-0024348-A1 | Substituted 6-Phenethyl-and phenylethenyl-3,4,5,6-tetrahydro-4-hydroxytetraydropyran-2-ones in the4-R trans stereoisomeric forms and the corresponding dihydroxy acids, process for preparing and pharmaceutical composition comprising them | MERCK & CO. INC. (US) | 1981-03-04 | — | — | EP | disclosed |