Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430796 | 0.86 | LTA4H (0.57) | MAPTRAB9AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL7430035 | 0.84 | ALDH1A1 (0.63) | MAPTRAB9ANPC1ALDH1A1L3MBTL1 | |
| SCHEMBL7438579 | 0.84 | MAPT (0.51) | MAPTRAB9ANPC1ALDH1A1L3MBTL1 | |
| SCHEMBL7438472 | 0.84 | RAB9A (0.59) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7441627 | 0.84 | ALDH1A1 (0.61) | MAPTRAB9ANPC1GFERALDH1A1 | |
| SCHEMBL7435769 | 0.84 | MAPT (0.60) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7436562 | 0.84 | PTGS2 (0.45) | MAPTRAB9ANPC1GFERALDH1A1 | |
| SCHEMBL7437056 | 0.82 | ATP4A (0.61) | MAPTRAB9ANPC1GFERALDH1A1 | |
| SCHEMBL6658975 | 0.81 | RAB9A (0.61) | MAPTRAB9ANPC1GFERALDH1A1 | |
| SCHEMBL7444819 | 0.81 | LTA4H (0.51) | MAPTRAB9AALDH1A1L3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |