Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018953 | 0.91 | GAA (0.41) | ALDH1A1HSD17B10SMN1; SMN2KDM4EGSK3B | |
| SCHEMBL6292394 | 0.89 | DHFR (0.47) | ALDH1A1TP53KDM4EMAPTPOLB | |
| SCHEMBL7148024 | 0.86 | KDM4E (0.39) | ALDH1A1TP53HSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL7441431 | 0.86 | PYGL (0.39) | ALDH1A1HSD17B10SMN1; SMN2KDM4EMAPT | |
| SCHEMBL7434003 | 0.84 | CACNA1D (0.33) | ALDH1A1SMN1; SMN2MEN1KMT2AADORA3 | |
| SCHEMBL7435806 | 0.84 | MEN1 (0.39) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7020208 | 0.83 | KDM4E (0.39) | ALDH1A1KDM4E | |
| SCHEMBL6292549 | 0.83 | DHFR (0.45) | ALDH1A1TP53KDM4EMAPTPOLB | |
| SCHEMBL7429502 | 0.82 | CYP2C9 (0.42) | ALDH1A1TP53HSD17B10KDM4EMAPT | |
| SCHEMBL7017886 | 0.82 | CACNA1D (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002062795-A9 | DIHYDROPYRAZOLOPYRIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2002-10-10 | — | — | WO | claimed |
| WO-2002062795-A9 | DIHYDROPYRAZOLOPYRIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2002-10-10 | — | — | WO | disclosed |