SCHEMBL7434604

SCHEMBL7434604

CCOC(=O)CC(C)NC(=O)C(c1ccccc1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.53
CYP2C19 P33261 2/20 0.53
CYP2D6 P10635 1/20 0.53
MMP8 P22894 1/20 0.48
LMNA P02545 1/20 0.46
ALDH1A1 P00352 3/20 0.45
TSHR P16473 2/20 0.45
KDM4E B2RXH2 2/20 0.44
MAPT P10636 1/20 0.44
CYP2C9 P11712 1/20 0.44
GAA P10253 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7426916 0.82 HDAC3 (0.52) LMNAALDH1A1KDM4EGAAL3MBTL1
SCHEMBL8972504 0.79 RAB9A (0.57) LMNAALDH1A1TSHRGAAL3MBTL1
SCHEMBL17695118 0.79 SIGMAR1 (0.49) CYP3A4CYP2C19CYP2D6MMP8ALDH1A1
SCHEMBL21209154 0.79 SIGMAR1 (0.49) CYP3A4CYP2C19CYP2D6MMP8ALDH1A1
SCHEMBL7966874 0.79 MMP8 (0.56) CYP3A4CYP2C19CYP2D6MMP8LMNA
SCHEMBL11443834 0.78 CYP3A4 (0.64) CYP3A4CYP2C19CYP2D6MMP8LMNA
SCHEMBL23027267 0.77 LTB4R (0.54) CYP3A4CYP2C19MMP8ALDH1A1TSHR
SCHEMBL563306 0.77 LTB4R (0.54) CYP3A4CYP2C19MMP8ALDH1A1TSHR
SCHEMBL13572924 0.77 LTB4R (0.54) CYP3A4CYP2C19MMP8ALDH1A1TSHR
SCHEMBL14521536 0.76 MGAM (0.46) CYP3A4CYP2D6ALDH1A1TSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5907068-A TRIFLUOROMETHYLSUBSTITUTED COMPOUND INCLUDED IN PEPTIDES ZENECA INC. (US) 1999-05-25 US disclosed
US-5726158-A INHIBITORS OF HUMAN LEUKOCYTE ELASTASE USEFUL IN TREATING TISSUE DEGENERATIVE DISEASES; TRIFLUOROMETHYL KETONE SUBSTITUTED DI-, TRI-, AND TETRA-PEPTIDE DERIVATIVES ZENECA INC. (US) 1998-03-10 US disclosed
US-5414132-A Peptide intermediates ZENECA INC. (US) 1995-05-09 US disclosed
US-5194588-A Inhibitors of human leukocyte elastase, di-, tri- and tetra-peptides ICI AMERICAS INC. (US) 1993-03-16 US disclosed
US-5055450-A Di-, tri- and tetrapeptides as inhibitors of human leukocyte elastase ICI AMERICAS INC. (US) 1991-10-08 US disclosed
US-4910190-A Containing a nitrogen containing heterocycle ring structure ICI AMERICAS INC. (US) 1990-03-20 US disclosed
EP-0189305-A2 Peptide derivatives ICI AMERICAS INC. (US) 1986-07-30 EP disclosed