Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434827 | 0.80 | HPGD (0.45) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7437345 | 0.80 | RAB9A (0.50) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7443165 | 0.76 | NPC1 (0.50) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7434681 | 0.76 | HCRTR2 (0.36) | NPC1RAB9AMAPTSMN1; SMN2HCRTR2 | |
| SCHEMBL7445875 | 0.76 | SMN1; SMN2 (0.55) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7437881 | 0.75 | ALDH1A1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2HCRTR2 | |
| SCHEMBL3568567 | 0.73 | HPGD (0.63) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL7436303 | 0.73 | RAB9A (0.50) | NPC1RAB9AMAPTSMN1; SMN2POLB | |
| SCHEMBL7446942 | 0.73 | GAA (0.45) | NPC1RAB9AMAPTSMN1; SMN2HCRTR2 | |
| SCHEMBL7426673 | 0.71 | HPGD (0.48) | RAB9AMAPTHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |