Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425049 | 0.92 | HDAC1 (0.40) | HDAC1GLSNAMPTBRD4CREBBP | |
| SCHEMBL7428732 | 0.76 | SMN1; SMN2 (0.44) | HDAC1NAMPTL3MBTL1 | |
| SCHEMBL7435758 | 0.74 | TP53 (0.34) | — | |
| SCHEMBL7428709 | 0.74 | GLS (0.39) | HDAC1GLSNAMPTBRD4CREBBP | |
| SCHEMBL7129747 | 0.74 | HDAC1 (0.42) | HDAC1GLSNAMPTBRD4CREBBP | |
| SCHEMBL7436590 | 0.73 | GLS (0.37) | HDAC1GLSNAMPTBRD4CREBBP | |
| SCHEMBL2787151 | 0.71 | GLS (0.58) | HDAC1GLSNAMPTBRD4CREBBP | |
| SCHEMBL185365 | 0.71 | ATM (0.55) | HDAC1GLSNAMPTBRD4L3MBTL1 | |
| SCHEMBL17171456 | 0.71 | GPR119 (0.46) | HDAC1GLSNAMPTL3MBTL1GAA | |
| SCHEMBL13055397 | 0.70 | KDM4A (0.51) | HDAC1GLSNAMPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |