Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.70 |
| ▸ | HTR3B | O95264 | 4/20 | 0.70 |
| ▸ | HTR3A | P46098 | 4/20 | 0.70 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.70 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444121 | 0.97 | NPC1 (0.71) | KMT2ANPC1MEN1HTR3EHTR3B | |
| SCHEMBL7300915 | 0.81 | HTR3E (0.52) | KMT2ANPC1MEN1HTR3EHTR3B | |
| SCHEMBL22639784 | 0.81 | RAB9A (1.00) | KMT2ANPC1MEN1RAB9ASMN1; SMN2 | |
| SCHEMBL1622809 | 0.81 | RAB9A (1.00) | KMT2ANPC1MEN1RAB9ASMN1; SMN2 | |
| SCHEMBL7430312 | 0.81 | HTR3A (0.58) | KMT2AMEN1HTR3EHTR3BHTR3A | |
| SCHEMBL7301719 | 0.81 | HTR3E (0.51) | KMT2ANPC1MEN1HTR3EHTR3B | |
| SCHEMBL13597998 | 0.79 | KMT2A (0.82) | KMT2ANPC1MEN1RAB9ASMN1; SMN2 | |
| SCHEMBL7308018 | 0.78 | HTR3A (0.50) | KMT2ANPC1MEN1HTR3EHTR3B | |
| SCHEMBL7430595 | 0.76 | HTR3A (0.67) | NPC1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7430349 | 0.75 | HTR3A (1.00) | NPC1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458636-B1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |