Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.70 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.66 |
| ▸ | HTR3B | O95264 | 5/20 | 0.66 |
| ▸ | HTR3A | P46098 | 5/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435902 | 0.97 | KMT2A (0.72) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL1622809 | 0.83 | RAB9A (1.00) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22639784 | 0.83 | RAB9A (1.00) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7308018 | 0.81 | HTR3A (0.50) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7300915 | 0.78 | HTR3E (0.52) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7430312 | 0.78 | HTR3A (0.58) | MEN1KMT2ASMN1; SMN2HTR3EHTR3B | |
| SCHEMBL13597998 | 0.78 | KMT2A (0.82) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7301719 | 0.77 | HTR3E (0.51) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7429752 | 0.77 | HTR3A (0.96) | NPC1RAB9AHTR3EHTR3BHTR3A | |
| SCHEMBL10673661 | 0.76 | HTR3A (0.78) | RAB9ASMN1; SMN2HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |