SCHEMBL743661

SCHEMBL743661

CCOC(=O)c1cc(Cl)ccn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.58
MAPT P10636 2/20 0.58
ALDH1A1 P00352 1/20 0.58
CYP1A2 P05177 1/20 0.50
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
NOTUM Q6P988 1/20 0.47
GABRA2 P47869 6/20 0.47
GABRB2 P47870 6/20 0.47
GABRP O00591 4/20 0.47
GABRD O14764 4/20 0.47
GABRA1 P14867 4/20 0.47
GABRB1 P18505 4/20 0.47
GABRG2 P18507 4/20 0.47
GABRB3 P28472 4/20 0.47
GABRA5 P31644 4/20 0.47
GABRA3 P34903 4/20 0.47
GABRA4 P48169 4/20 0.47
GABRE P78334 4/20 0.47
GABRA6 Q16445 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4217802 0.98 L3MBTL1 (0.56) L3MBTL1MAPTALDH1A1CYP1A2NPC1
Toluene SCHEMBL5966394 0.90 MAPT (0.49) L3MBTL1MAPTALDH1A1CYP1A2NPC1
SCHEMBL3558624 0.87 ALDH1A1 (0.55) L3MBTL1MAPTALDH1A1NPC1RAB9A
SCHEMBL5700280 0.84 L3MBTL1 (0.52) L3MBTL1MAPTALDH1A1CYP1A2NPC1
SCHEMBL25002932 0.84 GABRA2 (0.53) MAPTALDH1A1NPC1RAB9AGABRA2
SCHEMBL4305339 0.84 L3MBTL1 (0.46) L3MBTL1MAPTALDH1A1CYP1A2GABRA2
SCHEMBL18132229 0.83 L3MBTL1 (0.50) L3MBTL1MAPTALDH1A1CYP1A2NPC1
SCHEMBL127699 0.83 CYP1A2 (0.53) MAPTALDH1A1CYP1A2NPC1RAB9A
SCHEMBL4339936 0.81 MAPT (0.52) L3MBTL1MAPTALDH1A1NPC1RAB9A
SCHEMBL5778009 0.81 CA12 (0.51) MAPTALDH1A1CYP1A2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119019325-A Terpyridine iron complex, preparation method thereof and application thereof in photovoltaic cell temperature reduction and flow battery energy storage 西北大学 2024-11-26 CN claimed
CN-119019325-A Terpyridine iron complex, preparation method thereof and application thereof in photovoltaic cell temperature reduction and flow battery energy storage 西北大学 2024-11-26 CN disclosed
EP-3681883-B1 DIPHENYL DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2024-02-21 EP disclosed
CN-111094278-B Diphenyl derivative and use thereof 诺华股份有限公司 2023-07-14 CN disclosed
CN-110642837-B Pyridine amide compound containing triazole or quinolinone structure and application thereof 江西科技师范大学 2023-03-21 CN disclosed
US-10787443-B2 RAF-degrading conjugate compounds ZAMBONI CHEM SOLUTIONS INC. (CA) 2020-09-29 US disclosed
US-10787443-B2 RAF-degrading conjugate compounds ZAMBONI CHEM SOLUTIONS INC. (CA) 2020-09-29 US disclosed
EP-3681883-A1 DIPHENYL DERIVATIVES AND USES THEREOF Novartis AG (CH) 2020-07-22 EP disclosed
CN-111094278-A Diphenyl derivatives and their use 诺华股份有限公司 2020-05-01 CN disclosed
US-10633350-B2 Diphenyl derivatives and uses thereof NOVARTIS AG (CH) 2020-04-28 US disclosed
EP-1556468-A1 USE OF METAL COMPLEX COMPOUNDS AS CATALYSTS FOR OXIDATION USING MOLECULAR OXYGEN OR AIR Ciba SC Holding AG (CH) 2005-07-27 EP disclosed
WO-2005061688-A1 USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS RECKITT BENCKISER N.V. (NL) 2005-07-07 WO disclosed
WO-2005037794-A1 CYCLOHEXENE COMPOUNDS GLAXO GROUP LIMITED (GB) 2005-04-28 WO disclosed
EP-1521820-A1 USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS Ciba SC Holding AG (CH) 2005-04-13 EP disclosed
WO-2004039933-A1 USE OF METAL COMPLEX COMPOUNDS AS CATALYSTS FOR OXIDATION USING MOLECULAR OXYGEN OR AIR CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-05-13 WO disclosed
WO-2004039934-A1 USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-05-13 WO disclosed
WO-2004007657-A1 USE OF METAL COMPLEX COMPOUNDS AS OXIDATION CATALYSTS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-01-22 WO disclosed
US-4237300-A CHEMICAL INTERMEDIATES FOR IMIDAZO(1,2-A)PYRIDINE ANTHELMINTIC AGENTS AS WELL AS BEING A FUNGICIDE MERCK & CO., INC. (US) 1980-12-02 US disclosed
US-4177274-A ANTHELMINTICS MERCK & CO., INC. (US) 1979-12-04 US disclosed
US-4096264-A ANTHELMINTICS MERCK & CO., INC. (US) 1978-06-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10633350-B2 Diphenyl derivatives and uses thereof MYOF, NGF, MUSK L3MBTL1 1366/4885MAPT 2084/4885ALDH1A1 921/4885
US-10787443-B2 RAF-degrading conjugate compounds BRAF, RAF1, ARAF L3MBTL1 2047/4885MAPT 3879/4885ALDH1A1 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.