Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433751 | 0.80 | SLC1A2 (0.57) | ALDH1A1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL7434063 | 0.79 | CES2 (0.43) | ALDH1A1HTTSMN1; SMN2LMNACES2 | |
| SCHEMBL11619479 | 0.77 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2NCOA1NCOA3 | |
| SCHEMBL7441717 | 0.76 | TSHR (0.43) | ALDH1A1HTTSMN1; SMN2LMNACES2 | |
| SCHEMBL11717078 | 0.74 | ALDH1A1 (0.54) | ALDH1A1HTTSMN1; SMN2NCOA1NCOA3 | |
| SCHEMBL7488786 | 0.74 | SLC1A2 (0.50) | ALDH1A1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL7440146 | 0.72 | ALDH1A1 (0.59) | ALDH1A1HTTSMN1; SMN2NCOA1NCOA3 | |
| SCHEMBL7437423 | 0.72 | PPARA (0.47) | TRPA1ATM | |
| SCHEMBL7436814 | 0.71 | SMN1; SMN2 (0.47) | ALDH1A1HTTSMN1; SMN2RAB9ALMNA | |
| SCHEMBL7496499 | 0.71 | PPARG (0.48) | ALDH1A1HTTSMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |