Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | GUSB | P08236 | 1/20 | 0.74 |
| ▸ | CACNA1F | O60840 | 9/20 | 0.69 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.69 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.69 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | DHFR | P00374 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19752716 | 0.88 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL29531249 | 0.88 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL3394058 | 0.88 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7265815 | 0.85 | ALDH1A1 (0.83) | ALDH1A1L3MBTL1GUSBCACNA1FCACNA1D | |
| Monastrol SCHEMBL3168349 | 0.83 | KIF11 (0.77) | ALDH1A1GUSBDHFRKMT2APOLB | |
| S-Menastrol SCHEMBL74457 | 0.83 | KIF11 (0.77) | ALDH1A1GUSBDHFRKMT2APOLB | |
| SCHEMBL14164085 | 0.82 | DHFR (0.74) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL13302798 | 0.82 | DHFR (0.74) | ALDH1A1GUSBLMNADHFRMEN1 | |
| SCHEMBL14164090 | 0.82 | DHFR (0.74) | ALDH1A1LMNADHFRKMT2APOLB | |
| SCHEMBL2574894 | 0.82 | CACNA1F (1.00) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738615-B2 | Cyclophilin D inhibitors | THE UNIVERSITY OF KANSAS (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160075669-A1 | CYCLOPHILIN D INHIBITORS | THE UNIVERSITY OF KANSAS | 2016-03-17 | — | — | US | disclosed |
| US-4675321-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1987-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075669-A1 | CYCLOPHILIN D INHIBITORS | PPID, APP, PIN1 | ALDH1A1 2677/4885L3MBTL1 4134/4885GUSB 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.