Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438535 | 0.89 | EPHX2 (0.37) | MMP8ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL7049724 | 0.81 | PRNP (0.50) | ALDH1A1MAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL8181479 | 0.73 | MTNR1A (0.38) | ALDH1A1MAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL8530430 | 0.71 | ALDH1A1 (0.38) | MMP8ALDH1A1MAPTHPGDPIN1 | |
| SCHEMBL7440992 | 0.70 | MMP8 (0.43) | MMP8ALDH1A1MAPTKMT2A | |
| SCHEMBL7049694 | 0.69 | HSD17B10 (0.50) | MMP8KCNH2ALDH1A1MAPTHPGD | |
| SCHEMBL27332632 | 0.68 | POLB (0.39) | MMP8ALDH1A1MAPTHPGDPIN1 | |
| SCHEMBL7049701 | 0.67 | ALDH1A1 (0.36) | MMP8ALDH1A1MAPTHPGDPIN1 | |
| SCHEMBL1331369 | 0.67 | KCNH2 (0.58) | KCNH2ALDH1A1MAPTHPGDPOLB | |
| SCHEMBL722868 | 0.67 | KCNH2 (0.58) | KCNH2ALDH1A1MAPTHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013792-A | INTERSTITIAL COLLAGENASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIOSTEOPOROSIS AGENTS | SYNTEX (U.S.A.), INC. (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0712403-B1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996023791-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-08-08 | — | — | WO | disclosed |
| EP-0712403-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004735-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-02-16 | — | — | WO | disclosed |