Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 4/20 | 0.51 |
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | CPA1 | P15085 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916012 | 0.92 | MME (0.58) | MMP13ADAMTS4MMEACECPA1 | |
| SCHEMBL7514233 | 0.82 | MME (0.49) | MMP13ADAMTS4MMEACECPA1 | |
| SCHEMBL7447456 | 0.79 | MME (0.56) | MMP13MMEACECPA1ACE2 | |
| SCHEMBL7453286 | 0.78 | PDE4D (0.55) | MMEACECPA1ACE2CA2 | |
| SCHEMBL7405654 | 0.75 | SLC1A3 (0.60) | MMP13ADAMTS4MMP1MMP9ADAM17 | |
| SCHEMBL1656194 | 0.75 | ADAMTS4 (0.78) | MMP13ADAMTS4 | |
| SCHEMBL8283969 | 0.75 | ADAMTS4 (0.78) | MMP13ADAMTS4 | |
| SCHEMBL8389137 | 0.74 | MMP2 (0.69) | MMP13ADAMTS4ITGB3MMP1MMP9 | |
| SCHEMBL8647491 | 0.74 | MMP2 (0.69) | MMP13ADAMTS4ITGB3MMP1MMP9 | |
| SCHEMBL7451514 | 0.73 | ITGB3 (0.55) | ADAMTS4ITGB3ITGAVFPR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998282-A4 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2000-08-30 | — | — | EP | claimed |
| EP-0998282-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998053818-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 1998-12-03 | — | — | WO | claimed |