Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.58 |
| ▸ | ACE | P12821 | 9/20 | 0.58 |
| ▸ | CPA1 | P15085 | 9/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444546 | 0.92 | MMP13 (0.52) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL7447456 | 0.83 | MME (0.56) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL7514233 | 0.79 | MME (0.49) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL7453286 | 0.76 | PDE4D (0.55) | MMEACECPA1ACE2CA2 | |
| SCHEMBL8742293 | 0.75 | SLC1A3 (0.67) | MMP13ADAMTS4MMP1MMP9 | |
| SCHEMBL7133839 | 0.74 | SLC1A3 (0.45) | MMEACECPA1ACE2MMP13 | |
| SCHEMBL7451514 | 0.73 | ITGB3 (0.55) | ITGB3ITGAVADAMTS4FPR2MEN1 | |
| SCHEMBL7445482 | 0.73 | MME (0.58) | MMEACECPA1ACE2ITGB3 | |
| SCHEMBL8389137 | 0.73 | MMP2 (0.69) | ITGB3MMP13ADAMTS4MMP1MMP9 | |
| SCHEMBL8647491 | 0.73 | MMP2 (0.69) | ITGB3MMP13ADAMTS4MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221888-B1 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENT, AUTOIMMUNE DISEASE, RHEUMATIC DISORDERS | MERCK & CO., INC. | 2001-04-24 | — | — | US | claimed |