Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 10/20 | 0.47 |
| ▸ | MMP1 | P03956 | 8/20 | 0.47 |
| ▸ | MMP13 | P45452 | 8/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BMP1 | P13497 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506665 | 0.85 | MMP9 (0.47) | MMP9MMP1MMP13ADAM17KDM4E | |
| SCHEMBL7817619 | 0.85 | MMP1 (0.61) | MMP9MMP1MMP13ADAM17 | |
| SCHEMBL7825425 | 0.77 | MMP9 (0.77) | MMP9MMP1MMP13ADAM17 | |
| SCHEMBL7444339 | 0.77 | MMP1 (0.74) | MMP9MMP1MMP13ADAM17 | |
| SCHEMBL7315173 | 0.75 | MMP9 (0.62) | MMP9MMP1MMP13ADAM17KDM4E | |
| SCHEMBL7320832 | 0.73 | MMP1 (0.50) | MMP9MMP1MMP13ADAM17KDM4E | |
| SCHEMBL7311421 | 0.72 | MMP1 (0.81) | MMP9MMP1MMP13ADAM17KDM4E | |
| SCHEMBL5624488 | 0.72 | ALDH1A1 (0.60) | BMP1L3MBTL1CNR2KEAP1NFE2L2 | |
| SCHEMBL7444659 | 0.71 | MMP13 (0.59) | MMP9MMP1MMP13ADAM17KEAP1 | |
| SCHEMBL7317053 | 0.70 | MMP9 (0.46) | MMP9MMP1MMP13ADAM17KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |