Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445601 | 0.85 | DRD2 (0.42) | DRD2HTR1AHTR7KMT2ADRD3 | |
| SCHEMBL7442930 | 0.82 | DRD3 (0.54) | SLC6A4KCNH2HTR1ADRD3 | |
| SCHEMBL7445531 | 0.82 | SLC6A4 (0.41) | DRD2SLC6A4KCNH2HTR1AHTR7 | |
| SCHEMBL7442254 | 0.81 | ALDH1A1 (0.46) | ALDH1A1SLC6A4KCNH2LMNA | |
| SCHEMBL13434159 | 0.73 | SLC6A4 (0.58) | ALDH1A1SLC6A4KCNH2KMT2A | |
| SCHEMBL12640603 | 0.72 | HTR1A (0.43) | ALDH1A1DRD2LMNAHTR1AHTR7 | |
| SCHEMBL13911241 | 0.71 | SLC6A4 (0.56) | ALDH1A1SLC6A4KCNH2KMT2A | |
| SCHEMBL7444816 | 0.71 | SLC6A4 (0.44) | DRD2SLC6A4KCNH2DRD3 | |
| SCHEMBL13911269 | 0.69 | AGER (0.56) | ALDH1A1SLC6A4KCNH2KMT2A | |
| SCHEMBL12355698 | 0.68 | CHRNB2 (0.40) | ALDH1A1DRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |