Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221210 | 0.86 | MAOA (0.53) | ALDH1A1NPC1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL7651607 | 0.86 | MAOA (0.53) | ALDH1A1NPC1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL2237332 | 0.86 | MAOA (0.53) | ALDH1A1NPC1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL25933057 | 0.84 | TDP1 (0.59) | ALDH1A1NPC1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL6777555 | 0.84 | IDO1 (0.44) | ALDH1A1RAB9ATDP1CYP1A2CYP3A4 | |
| SCHEMBL11353500 | 0.83 | TDP1 (0.54) | ALDH1A1NPC1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL1157774 | 0.80 | KIF11 (0.50) | ALDH1A1NPC1SMN1; SMN2RAB9AMTNR1A | |
| SCHEMBL1157769 | 0.80 | KIF11 (0.50) | ALDH1A1NPC1SMN1; SMN2RAB9AMTNR1A | |
| SCHEMBL1157776 | 0.80 | KIF11 (0.50) | ALDH1A1NPC1SMN1; SMN2RAB9AMTNR1A | |
| SCHEMBL11512840 | 0.79 | METAP2 (0.52) | ALDH1A1NPC1SMN1; SMN2RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119161-B1 | BENZAZOCINONE AND BENZAZONINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THEIR THERAPEUTICAL USE | CIBA-GEIGY AG (CH) | 1989-06-28 | — | — | EP | disclosed |
| US-4575503-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1986-03-11 | — | — | US | disclosed |
| US-4537885-A | SUBSTITUTED 1-CARBOXY-3-(CARBOXYMETHYLAMINO)-2-ONE DERIVATIVES, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | CIBA GEIGY CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0119161-A2 | Benzazocinone and benzazoninone derivatives, process for their preparation, pharmaceutical preparations containing these compounds, and their therapeutical use | CIBA-GEIGY AG (CH) | 1984-09-19 | — | — | EP | disclosed |