Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388331 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1EPHB4CYP3A4ALDH1A1 | |
| SCHEMBL7445894 | 0.81 | PTGS2 (0.42) | PTGS2PTGS1EPHB4CYP3A4ALDH1A1 | |
| SCHEMBL7443976 | 0.80 | CYP3A4 (0.46) | CYP3A4ALDH1A1TSHRSMN1; SMN2TP53 | |
| SCHEMBL15832034 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1EPHB4PIM1SRC | |
| SCHEMBL31161110 | 0.77 | PTGS2 (0.58) | PTGS2PTGS1EPHB4CYP3A4ALDH1A1 | |
| SCHEMBL397260 | 0.77 | PTGS2 (0.58) | PTGS2PTGS1EPHB4CYP3A4ALDH1A1 | |
| SCHEMBL27926878 | 0.77 | SMN1; SMN2 (0.46) | CYP3A4ALDH1A1TSHRPIM1SRC | |
| SCHEMBL15832014 | 0.76 | CYP11B2 (0.46) | PTGS2PTGS1IDO1 | |
| SCHEMBL8227809 | 0.76 | MEN1 (0.50) | PTGS2SMN1; SMN2MEN1NPC1LMNA | |
| SCHEMBL10713204 | 0.76 | TDP1 (0.54) | PTGS2PTGS1CYP3A4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |