Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444699 | 0.85 | AHR (0.46) | PTGS1APPPSEN1PSEN2APH1B | |
| SCHEMBL7442456 | 0.83 | ADRB2 (0.44) | PTGS1ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL7446405 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL3388331 | 0.80 | PTGS2 (0.46) | PTGS2PTGS1EPHB4ALDH1A1CYP3A4 | |
| SCHEMBL530400 | 0.79 | SLC6A2 (0.44) | PTGS2PTGS1PGRALDH1A1CYP3A4 | |
| SCHEMBL17486766 | 0.79 | SLC6A2 (0.44) | PTGS2PTGS1PGRALDH1A1CYP3A4 | |
| SCHEMBL14041057 | 0.76 | RXRA (0.49) | PTGS2PTGS1PGRCYP3A4TSHR | |
| SCHEMBL29901014 | 0.75 | ALDH1A1 (0.56) | PTGS1ALDH1A1GAAALOX12HTT | |
| SCHEMBL31161110 | 0.75 | PTGS2 (0.58) | PTGS2PTGS1EPHB4ALDH1A1CYP3A4 | |
| SCHEMBL12618445 | 0.75 | LMNA (0.42) | PTGS2PTGS1APPPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |