Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450677 | 0.78 | ITGB3 (0.40) | CYP3A4KMT2AHTR4ALDH1A1KDM4E | |
| SCHEMBL7448756 | 0.76 | GNAO1 (0.38) | L3MBTL1HTR4ALDH1A1 | |
| SCHEMBL7257999 | 0.75 | ALDH1A1 (0.52) | PKMCYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL7447186 | 0.75 | GNAO1 (0.43) | HTR4ALDH1A1KDM4E | |
| SCHEMBL7251884 | 0.75 | HDAC3 (0.61) | L3MBTL1PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL5212781 | 0.74 | L3MBTL1 (0.56) | L3MBTL1HTR2AHTR2CPKMCYP3A4 | |
| SCHEMBL7446777 | 0.74 | GNAO1 (0.40) | CYP2C19KMT2AHTR4ALDH1A1KDM4E | |
| SCHEMBL1797016 | 0.73 | MAPT (0.69) | L3MBTL1PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL6011594 | 0.73 | CRBN (0.46) | HTR2AHTR2CCYP3A4CYP2C19KMT2A | |
| SCHEMBL27479780 | 0.73 | L3MBTL1 (0.73) | L3MBTL1HTR2AHTR2CPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | disclosed |