SCHEMBL745181

SCHEMBL745181

O=Cc1ccc(F)c(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 9/20 0.46
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
TDP1 Q9NUW8 2/20 0.39
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
THRB P10828 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.39
KCNJ1 P48048 1/20 0.35
CTSL P07711 1/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31306389 0.89 TDP1 (0.47) ERN1TDP1MEN1LMNATHRB
SCHEMBL31306390 0.89 TDP1 (0.47) ERN1TDP1MEN1LMNATHRB
SCHEMBL1806887 0.89 TDP1 (0.47) ERN1TDP1MEN1LMNATHRB
SCHEMBL1816745 0.80 ERN1 (0.43) ERN1CES2CES1TDP1MEN1
SCHEMBL659120 0.80 ERN1 (0.43) ERN1TDP1MEN1LMNATHRB
SCHEMBL24525370 0.78 ERN1 (0.42) ERN1TDP1MEN1LMNATHRB
SCHEMBL2263615 0.78 ERN1 (0.63) ERN1TDP1
SCHEMBL584614 0.78 ERN1 (0.42) ERN1TDP1MEN1LMNATHRB
SCHEMBL13929083 0.78 ERN1 (0.42) ERN1TDP1MEN1LMNATHRB
SCHEMBL7762075 0.78 TDP1 (0.45) ERN1TDP1MEN1LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 866 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118103371-B EGFR inhibitor and preparation method and application thereof SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-119798970-A High-temperature-resistant power tube and production process thereof 赣州祺琳新材料有限公司 2025-04-11 CN claimed
CN-118895668-A High-waterproofness fabric 南通东润智能科技有限公司 2024-11-05 CN claimed
CN-114409556-B Preparation method of 3, 4-disubstituted-2-aminobenzaldehyde 兰州康鹏威耳化工有限公司 2024-10-18 CN claimed
CN-118459420-A Thiazolinone compound containing multiple halogen atoms and preparation method thereof 南京工业大学 2024-08-09 CN claimed
CN-118459422-A Thiazole thiazolinone compound containing multiple halogen atoms and preparation method thereof 南京工业大学 2024-08-09 CN claimed
CN-115611717-B Preparation method of polyfluorobenzaldehyde 上海万溯药业有限公司 2024-06-28 CN claimed
CN-118103371-A EGFR inhibitor and preparation method and application thereof 山东新时代药业有限公司 2024-05-28 CN claimed
CN-115745766-B Preparation method of trifluorobenzaldehyde and trifluorobenzyl bromide 兰州康鹏威耳化工有限公司 2024-05-14 CN claimed
US-20240033318-A1 PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION OHIO STATE INNOVATION FOUNDATION 2024-02-01 US claimed
US-9422299-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists EUROSCREEN SA (BE) 2016-08-23 US claimed
CN-104151150-A Preparation method of 3,4-di(3,4,5-trifluorophenyl)-2,5-diphenylcyclopentyldienone UNIV SHANDONG 2014-11-19 CN claimed
CN-102617647-A Terpyridyl ruthenium coordination compound, and preparation method and application thereof UNIV SUN YAT SEN 2012-08-01 CN claimed
CN-101754960-A tetrahydropyranochromene gamma-secretase inhibitors SCHERING CORP 2010-06-23 CN claimed
US-20060084176-A1 Detection of uronium salts YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-04-20 US claimed
US-20050239853-A1 New compounds BIOVITRUM AB (SE) 2005-10-27 US claimed
WO-2005075471-A2 THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS BIOVITRUM AB (SE) 2005-08-18 WO claimed
US-20020146633-A1 FLUORINATED AROMATIC ACETAL POLYMERS AND PHOTOSENSITIVE COMPOSITIONS CONTAINING SUCH POLYMERS KODAK POLYCHROME GRAPHICS L.L.C. 2002-10-10 US claimed
US-6458503-B1 BLEND WITH DIAZO RESIN; LITHOGRAPHIC PRINTING PLATES; PHOTOPOLYMERIZATION AND CROSSLINKING KODAK POLYCHROME GRAPHICS LLC 2002-10-01 US claimed
WO-2002073315-A1 FLUORINATED AROMATIC ACETAL POLYMERS AND PHOTOSENSITIVE COMPOSITIONS CONTAINING SUCH POLYMERS KODAK POLYCHROME GRAPHICS COMPANY, LTD. (US) 2002-09-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050239853-A1 New compounds HSD11B1, CYP11B1, HSD3B1 ERN1 1308/4885CES2 183/4885CES1 28/4885
US-20240033318-A1 PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION CHP1, NFATC1, PPP3R1 ERN1 1903/4885CES2 2886/4885CES1 3249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.