SCHEMBL7452154

SCHEMBL7452154

CC(=O)C1(N)c2ccccc2CC1C

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.38
LMNA P02545 1/20 0.36
BLM P54132 1/20 0.36
KDM1A O60341 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL28943323 0.79 LMNA (0.41) NOTUMLMNABLMKDM1A
SCHEMBL2466865 0.73 KDM1A (0.43) KDM1A
Fumaric Acid SCHEMBL28943372 0.72 LMNA (0.53) LMNABLM
SCHEMBL7351257 0.71 KMT2A (0.40) LMNABLM
SCHEMBL7824370 0.71 LMNA (0.43) LMNABLM
SCHEMBL9054248 0.70 KDM1A (0.45) KDM1A
SCHEMBL9053824 0.70 KDM1A (0.41) KDM1A
SCHEMBL6071126 0.70 GAA (0.40) LMNABLM
SCHEMBL15609154 0.70 LMNA (0.36) LMNABLM
SCHEMBL7737636 0.70 SIGMAR1 (0.37) LMNABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0738149-A4 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMA (IL) 1999-10-27 EP disclosed
EP-0738149-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 1996-10-23 EP disclosed
WO-1995018617-A1 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 1995-07-13 WO disclosed