Sugi Predict

Sugi Predict / Compounds / SCHEMBL745249

SCHEMBL745249

SCHEMBL745249

O=S(=O)(Cl)c1ccccc1I

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ TRPV4 Q9HBA0 3/20 0.39
▸ GAA P10253 1/20 0.36
▸ HTR6 P50406 3/20 0.35
▸ CA1 P00915 4/20 0.34
▸ CA2 P00918 4/20 0.34
▸ CA6 P23280 3/20 0.34
▸ CA9 Q16790 3/20 0.34
▸ CA4 P22748 2/20 0.34
▸ CA12 O43570 2/20 0.34
▸ CYP2C9 P11712 2/20 0.34
▸ CA5A P35218 2/20 0.34
▸ CA7 P43166 2/20 0.34
▸ CA5B Q9Y2D0 2/20 0.34
▸ CA14 Q9ULX7 1/20 0.34
▸ ITGAV P06756 1/20 0.34
▸ PLCG1 P19174 1/20 0.32
▸ MGLL Q99685 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29515914 1.00 ALDH1A1 (0.44) ALDH1A1HSD17B10TDP1TRPV4GAA
SCHEMBL250199 0.81 ALDH1A1 (0.55) ALDH1A1HSD17B10TDP1TRPV4GAA
SCHEMBL648702 0.80 BCAT2 (0.40) GAAHTR6CA1CA2CA6
SCHEMBL1682100 0.79 GAA (0.50) GAAHTR6CA1CA2CA6
SCHEMBL9467299 0.78 CYP3A4 (0.45) ALDH1A1HSD17B10TDP1TRPV4HTR6
SCHEMBL7430693 0.77 GAA (0.37) GAAHTR6CA1CA2CA6
SCHEMBL9745397 0.77 GAA (0.37) GAAHTR6CA1CA2CA6
SCHEMBL1471236 0.75 CA2 (0.56) GAACA1CA2CA6CA9
SCHEMBL2893446 0.75 CA1 (0.39) GAAHTR6CA1CA2CA6
SCHEMBL7990343 0.75 GAA (0.36) ALDH1A1GAAHTR6CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119425423-A Positively charged composite membrane and preparation method and application thereof 中国石油化工股份有限公司 2025-02-14 — — CN claimed
CN-105669507-B A kind of molecule bridging agent and preparation method thereof and the application in Raman microprobe 辽宁大学 2017-11-14 — — CN claimed
CN-105669507-A Molecular bridging agent and preparation method and application thereof in Raman probe 辽宁大学 2016-06-15 — — CN claimed
CN-103910590-B A kind of biaryl compounds and preparation method thereof SHAOXING UNIVERSITY (CN) 2015-12-02 — — CN claimed
CN-103910590-A Biaryl compound and preparation method thereof UNIV SHAOXING 2014-07-09 — — CN claimed
US-20250339388-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF MAXYMUNE THERAPEUTICS INC (US) 2025-11-06 — — US disclosed
US-20250319046-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF MAXYMUNE THERAPEUTICS INC (US) 2025-10-16 — — US disclosed
US-12427124-B1 Phenylalanine-based LAT1 inhibitors and uses thereof Maxymune Therapeutics, Inc. (US) 2025-09-30 — — US disclosed
CN-119425423-A Positively charged composite membrane and preparation method and application thereof 中国石油化工股份有限公司 2025-02-14 — — CN disclosed
US-20240092802-A1 MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR KURES, INC. 2024-03-21 — — US disclosed
CN-111821503-B Radiopaque high-efficiency drug-loaded embolism microsphere and preparation and application thereof 苏州恒瑞宏远医疗科技有限公司 2022-07-12 — — CN disclosed
EP-3116509-B1 A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS UNIV COLUMBIA (US) 2022-06-22 — — EP disclosed
US-5624842-A Strain of Streptomyces for the production of tricyclo compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-29 — — US disclosed
EP-0752986-A1 N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LIMITED (GB) 1997-01-15 — — EP disclosed
EP-0749964-A1 N-Heterocyclyl biphenyl sulfonamides ZENECA LIMITED (GB) 1996-12-27 — — EP disclosed
WO-1995026957-A1 N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LIMITED (GB) 1995-10-12 — — WO disclosed
US-5294620-A Hypotensive agents or compounds for cardiovascular disorders IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1994-03-15 — — US disclosed
US-5217976-A Hypotensive agents, congestive heart failure IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-06-08 — — US disclosed
EP-0516392-A2 Naphthyridine derivatives as angiotensin II inhibitors ZENECA LIMITED (GB) 1992-12-02 — — EP disclosed
US-4060549-A Process for preparing sulfonic acid fluorides BAYER AKTIENGESELLSCHAFT (DT) 1977-11-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240092802-A1 MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR OPRL1, OPRM1, CDKL5 ALDH1A1 2985/4885HSD17B10 1324/4885TDP1 1093/4885
US-20250339388-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF SLC43A1, SLC7A1, SLC1A5 ALDH1A1 2745/4885HSD17B10 2654/4885TDP1 1176/4885
US-12427124-B1 Phenylalanine-based LAT1 inhibitors and uses thereof SLC43A1, SLC7A1, SLC1A5 ALDH1A1 2745/4885HSD17B10 2654/4885TDP1 1176/4885
US-20250319046-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF SLC43A1, SLC7A1, SLC1A5 ALDH1A1 2745/4885HSD17B10 2654/4885TDP1 1176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.