Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 2/20 | 0.31 |
| ▸ | ADH1C | P00326 | 2/20 | 0.31 |
| ▸ | ADH1A | P07327 | 2/20 | 0.31 |
| ▸ | ADH7 | P40394 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453266 | 0.77 | LMNA (0.36) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL7456996 | 0.75 | CTSC (0.38) | CES2CES1KEAP1MAPTTP53 | |
| SCHEMBL144586 | 0.74 | ALOX5 (0.38) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL142885 | 0.71 | TAS1R3 (0.36) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL11314837 | 0.70 | FFAR1 (0.46) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL141982 | 0.69 | HTT (0.40) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL11169009 | 0.68 | HTT (0.36) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL10458682 | 0.67 | ALOX5 (0.43) | LMNACES2CES1KEAP1MAPT | |
| SCHEMBL11309726 | 0.66 | CES2 (0.36) | CES2CES1KEAP1MAPTALOX5 | |
| SCHEMBL7534282 | 0.66 | SMN1; SMN2 (0.38) | LMNATP53POLBADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027096-A9 | AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | PROTHERICS MOLECULAR DESIGN LT (GB) | 2001-07-12 | — | — | WO | disclosed |