Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622988 | 0.95 | POLB (0.46) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL7331165 | 0.95 | POLB (0.46) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL7418023 | 0.90 | CTSK (0.47) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL4633702 | 0.90 | CTSK (0.47) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL5497072 | 0.90 | CTSK (0.47) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL5188450 | 0.88 | CTSK (0.47) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL5187344 | 0.88 | CTSK (0.47) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL9327711 | 0.86 | CTSK (0.48) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL7438556 | 0.86 | CTSK (0.46) | POLBGAAMAPTXBP1NPSR1 | |
| SCHEMBL8385337 | 0.85 | ALDH1A1 (0.49) | TDP1CTSKCTSBCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960108-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998033788-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-08-06 | — | — | WO | disclosed |