Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | C1R | P00736 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7464567 | 0.91 | TAS2R14 (0.40) | TAS2R14PTGESTAS2R8ALDH1A1KMT2A | |
| Bromide SCHEMBL8066350 | 0.90 | PTGES (0.45) | HSP90AA1TAS2R14TP53PTGESLMNA | |
| SCHEMBL10691854 | 0.90 | TAS2R14 (0.41) | TAS2R14PTGESTAS2R8ALDH1A1KMT2A | |
| Bromide SCHEMBL7469202 | 0.89 | KMT2A (0.48) | HSP90AA1TP53LMNAMAPTALDH1A1 | |
| SCHEMBL7471994 | 0.86 | KEAP1 (0.47) | HSP90AA1TAS2R14TP53PTGESTAS2R8 | |
| Bromide SCHEMBL8076530 | 0.86 | KEAP1 (0.46) | HSP90AA1TAS2R14TP53PTGESLMNA | |
| SCHEMBL9407899 | 0.84 | ALDH1A1 (0.43) | HSP90AA1TP53LMNAMAPTALDH1A1 | |
| Bromide SCHEMBL8076287 | 0.84 | KEAP1 (0.43) | HSP90AA1TP53LMNAMAPTALDH1A1 | |
| SCHEMBL8076269 | 0.80 | ALDH1A1 (0.42) | HSP90AA1TAS2R14TP53PTGESTAS2R8 | |
| SCHEMBL7470894 | 0.79 | KMT2A (0.44) | HSP90AA1TP53LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647628-B1 | Acridinium derivatives and their use in luminescence immunoassays | DADE BEHRING MARBURG GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-0257541-B1 | Chemilumuniscent acridine derivatives and their use in luminescence immunoassays | HOECHST AG (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0647628-A1 | Acridmium derivatives and their use in luminescence immunoassays | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-12 | — | — | EP | disclosed |
| EP-0257541-A2 | Chemilumuniscent acridine derivatives and their use in luminescence immunoassays | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-03-02 | — | — | EP | disclosed |