Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31004955 | 0.96 | TUBB1 (0.54) | FDPSHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL29254188 | 0.96 | TUBB1 (0.54) | FDPSHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL15553481 | 0.90 | ALDH1A1 (0.50) | FDPSHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL7457620 | 0.89 | TUBB1 (0.55) | FDPSALDH1A1MAPK1CYP1A2TUBB1 | |
| SCHEMBL6850758 | 0.88 | ALDH1A1 (0.58) | ALDH1A1CYP1A2TUBB1CYP1A1CYP2D6 | |
| SCHEMBL14835707 | 0.88 | ALDH1A1 (0.68) | FDPSALDH1A1MAPK1CYP1A2TUBB1 | |
| SCHEMBL7466433 | 0.85 | FDPS (0.53) | FDPSALDH1A1MAPK1CYP1A2TUBB1 | |
| SCHEMBL3572644 | 0.85 | ALDH1A1 (0.54) | FDPSALDH1A1MAPK1CYP1A2TUBB1 | |
| SCHEMBL8165089 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPK1CYP1A2TUBB1CYP1A1 | |
| SCHEMBL7462928 | 0.84 | FDPS (0.51) | FDPSALDH1A1MAPK1TUBB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324684-A | Antitumor compound and pharmaceutical composition and application thereof | 上海中医药大学 | 2024-07-12 | — | — | CN | disclosed |
| WO-2021058483-A1 | PROCESS FOR PRODUCING LIGNIN COMPONENTS FROM LIGNOCELLULOSIC BIOMASS | Université Catholique de Louvain (BE) | 2021-04-01 | — | — | WO | disclosed |
| CN-107162989-A | A kind of preparation method of trimethoprim impurity | 山东新华制药股份有限公司 | 2017-09-15 | — | — | CN | disclosed |
| US-9249115-B2 | N,N1 substituted piperazines having combined antiaggregant, anticoagulant and vasodilatory activity, and method for producing same | VERTEX CLOSED JOINT STOCK COMPANY (RU) | 2016-02-02 | — | — | US | disclosed |
| US-20130267707-A1 | N,N+hu 1 +l SUBSTITUTED PIPERAZINES HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATORY ACTIVITY, AND METHOD FOR PRODUCING SAME | ZAKRYTOE AKTSIONERNOE OBSCHSHESTVO "VERTEX" (RU) | 2013-10-10 | — | — | US | disclosed |
| US-20130131018-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | EXONHIT S.A. (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20130131018-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | EXONHIT S.A. (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20130131018-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | EXONHIT S.A. (FR) | 2013-05-23 | — | — | US | disclosed |
| EP-2576514-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | EXONHIT SA (FR) | 2013-04-10 | — | — | EP | disclosed |
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED | 2013-01-24 | — | — | US | disclosed |
| WO-1999025716-A2 | PYRANONES, METHOD FOR THE PRODUCTION AND USE THEREOF | DR. WILLMAR SCHWABE GMBH & CO. (DE) | 1999-05-27 | — | — | WO | disclosed |
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5380759-A | Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia | BURROUGHS WELLCOME CO. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5371219-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |
| CN-1085901-A | Preparation contains the method for the antineoplastic pharmaceutical compositions of Imidazopyridazine derivative | WELLCOME FOUND (GB) | 1994-04-27 | — | — | CN | disclosed |
| EP-0305093-B1 | Imidazo(1,2-b)pyridazine derivatives | WELLCOME FOUND (GB) | 1994-04-06 | — | — | EP | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| CN-1031532-A | HETEROCYCLIC COMPOUNDS | WELLCOME FOUND (GB) | 1989-03-08 | — | — | CN | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | KCNB1, KCNB2, SCNN1B | FDPS 1944/4885HTR2A 788/4885HTR2C 1097/4885 |
| US-20130131018-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | TUBB3, TUBB, TUBB1 | FDPS 1240/4885HTR2A 4202/4885HTR2C 3841/4885 |
| US-20130267707-A1 | N,N+hu 1 +l SUBSTITUTED PIPERAZINES HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATORY ACTIVITY, AND METHOD FOR PRODUCING SAME | HCN1, HCN3, HCN2 | FDPS 4534/4885HTR2A 682/4885HTR2C 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.