Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31148931 | 0.80 | POLB (0.48) | HSD11B1ALDH1A1KDM4ECA2CA1 | |
| SCHEMBL9364060 | 0.80 | POLB (0.48) | HSD11B1ALDH1A1KDM4ECA2CA1 | |
| SCHEMBL9312078 | 0.79 | CA2 (0.45) | RBP4HSD11B1ALDH1A1TDP1TSHR | |
| SCHEMBL4600270 | 0.79 | NPSR1 (0.37) | RBP4HSD11B1ALDH1A1TDP1TSHR | |
| SCHEMBL382488 | 0.79 | RBP4 (0.35) | RBP4HSD11B1ALDH1A1TDP1TSHR | |
| SCHEMBL27561927 | 0.77 | CTSB (0.42) | HSD11B1CA2CA1CA5ACA9 | |
| SCHEMBL28859539 | 0.76 | CA1 (0.53) | TDP1CA2CA1CA5ACA9 | |
| SCHEMBL27466835 | 0.76 | HSD11B1 (0.41) | RBP4HSD11B1ALDH1A1TDP1TSHR | |
| SCHEMBL28846537 | 0.75 | POLB (0.43) | HSD11B1ALDH1A1TDP1KDM4ECA2 | |
| SCHEMBL29851275 | 0.75 | ALDH1A1 (0.43) | RBP4HSD11B1ALDH1A1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946502-A1 | SULFONAMIDE INTERLEUKIN-BETA CONVERTING ENZYME INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998016505-A1 | SULFONAMIDE INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |