Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.57 |
| ▸ | MMP1 | P03956 | 4/20 | 0.57 |
| ▸ | MMP2 | P08253 | 3/20 | 0.57 |
| ▸ | MMP14 | P50281 | 2/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 2/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.52 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.50 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.49 |
| ▸ | ADAM8 | P78325 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411093 | 0.90 | MMP13 (0.60) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL7413161 | 0.89 | MMP2 (0.53) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL31086993 | 0.88 | MMP13 (0.57) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL7417303 | 0.86 | MMP1 (0.68) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL7461414 | 0.85 | MMP13 (0.56) | MMP13MMP1MMP2MMP3ADAM17 | |
| SCHEMBL7419743 | 0.84 | MMP2 (0.69) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL7420442 | 0.81 | MMP1 (0.69) | MMP13MMP1MMP2MMP14ADAMTS4 | |
| SCHEMBL4921260 | 0.81 | MMP9 (0.51) | MMP13MMP1MMP2MMP14ADAM17 | |
| SCHEMBL4921267 | 0.81 | MMP9 (0.51) | MMP13MMP1MMP2MMP14ADAM17 | |
| SCHEMBL2513418 | 0.81 | MMP13 (0.50) | MMP13MMP1MMP2MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |