Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
| ▸ | MMP9 | P14780 | 5/20 | 0.53 |
| ▸ | MMP14 | P50281 | 4/20 | 0.53 |
| ▸ | ADAM10 | O14672 | 4/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.53 |
| ▸ | ADAM8 | P78325 | 3/20 | 0.53 |
| ▸ | MMP12 | P39900 | 2/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.50 |
| ▸ | BMP1 | P13497 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464064 | 0.89 | MMP13 (0.57) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL7413144 | 0.87 | BMP1 (0.60) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL7411093 | 0.86 | MMP13 (0.60) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL3937333 | 0.85 | ADAM17 (0.67) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL31086993 | 0.84 | MMP13 (0.57) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL1800019 | 0.83 | MMP2 (0.62) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL1802607 | 0.82 | MMP2 (0.52) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL7409720 | 0.82 | MMP9 (0.60) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL3948016 | 0.82 | ADAM17 (0.68) | MMP2MMP9MMP14ADAM10ADAM17 | |
| SCHEMBL2922135 | 0.82 | ITGB3 (0.52) | MMP2MMP9MMP13MMP3ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |