Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472590 | 0.91 | HDAC6 (0.54) | SMN1; SMN2HPGDHDAC6HDAC8HDAC1 | |
| SCHEMBL7472478 | 0.89 | CCR2 (0.50) | SMN1; SMN2HPGDHDAC6HDAC8HDAC1 | |
| SCHEMBL7460713 | 0.84 | MAPK8 (0.55) | SMN1; SMN2HPGDHDAC6HDAC8HDAC1 | |
| SCHEMBL7461866 | 0.83 | MEN1 (0.48) | SMN1; SMN2MAPTKDM4EMAPK1L3MBTL1 | |
| SCHEMBL7468517 | 0.81 | HDAC6 (0.52) | SMN1; SMN2HDAC6HDAC8HDAC1MAPT | |
| SCHEMBL7472835 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDHDAC6HDAC8HDAC1 | |
| SCHEMBL7470273 | 0.78 | CCR2 (0.47) | HDAC6HDAC8HDAC1MAPTMAPK8 | |
| SCHEMBL7465874 | 0.78 | AKR1B1 (0.50) | HDAC6 | |
| SCHEMBL7465240 | 0.77 | CMA1 (0.44) | SMN1; SMN2HPGDHDAC6HDAC8HDAC1 | |
| SCHEMBL7465395 | 0.77 | TP53 (0.51) | SMN1; SMN2HPGDHDAC6MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |