Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | PARG | Q86W56 | 3/20 | 0.46 |
| ▸ | CLPP | Q16740 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459226 | 0.90 | PARG (0.44) | PARGMAPK8MAPK9HDAC6HDAC8 | |
| SCHEMBL7460713 | 0.86 | MAPK8 (0.55) | MAPTMAPK8MAPK9HDAC6HDAC8 | |
| SCHEMBL7472478 | 0.82 | CCR2 (0.50) | CCR2MAPTMAPK8MAPK9HDAC6 | |
| SCHEMBL7463851 | 0.81 | NOX4 (0.46) | PARGMAPK8MAPK9CMA1MEN1 | |
| SCHEMBL7466124 | 0.80 | CMA1 (0.46) | PARGMAPTMAPK8MAPK9HDAC6 | |
| SCHEMBL7461329 | 0.80 | CMA1 (0.46) | PARGMAPTMAPK8MAPK9HDAC6 | |
| SCHEMBL4456863 | 0.80 | GABRA5 (0.53) | PARGMAPK8MAPK9CMA1LMNA | |
| SCHEMBL7465634 | 0.78 | SMN1; SMN2 (0.49) | MAPTMAPK8MAPK9HDAC6HDAC8 | |
| SCHEMBL7462052 | 0.78 | KMT2A (0.47) | PARGMAPTMAPK8MAPK9HDAC6 | |
| SCHEMBL7468517 | 0.78 | HDAC6 (0.52) | MAPTMAPK8MAPK9HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |