Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.51 |
| ▸ | USP5 | P45974 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465634 | 0.91 | SMN1; SMN2 (0.49) | HDAC6HDAC1HDAC8EGLN2EGLN1 | |
| SCHEMBL7468517 | 0.88 | HDAC6 (0.52) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7460713 | 0.83 | MAPK8 (0.55) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7470753 | 0.81 | NAMPT (0.55) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7472478 | 0.81 | CCR2 (0.50) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7461329 | 0.81 | CMA1 (0.46) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7465874 | 0.81 | AKR1B1 (0.50) | HDAC6 | |
| SCHEMBL7468017 | 0.79 | HDAC6 (0.45) | HDAC6HDAC1HDAC8SMN1; SMN2MAPT | |
| SCHEMBL7466124 | 0.79 | CMA1 (0.46) | HDAC6HDAC1HDAC8MAPTTP53 | |
| SCHEMBL7462052 | 0.78 | KMT2A (0.47) | HDAC6HDAC1HDAC8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |