Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30047375 | 1.00 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL28806287 | 0.86 | BRD4 (0.43) | ALDH1A1KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL18405111 | 0.83 | KDM4E (0.45) | ALDH1A1KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL14822759 | 0.81 | RIPK1 (0.44) | ALDH1A1KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL14822757 | 0.81 | CYP3A4 (0.48) | ALDH1A1KMT2AMEN1MAPTCYP19A1 | |
| SCHEMBL27407526 | 0.79 | BRD4 (0.46) | ALDH1A1KMT2AMEN1MAPTBRD4 | |
| SCHEMBL3809851 | 0.78 | TP53 (0.45) | MAPTBRD4CYP3A4CYP2C9GAA | |
| SCHEMBL1953678 | 0.78 | BRD4 (0.43) | KMT2AMEN1MAPTBRD4CYP1A2 | |
| SCHEMBL2202098 | 0.78 | GAA (0.50) | KMT2AMEN1MAPTL3MBTL1CYP19A1 | |
| SCHEMBL30364150 | 0.78 | GAA (0.50) | KMT2AMEN1MAPTL3MBTL1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025981-A1 | PROCESS FOR THE PREPARATION OF METHYL 4,6-DIAMINO-2-[L-(2-FHIOROBENZVR)-LH-PYRAZOLO I3,4-BLPVRIDIN-3-VN-5-PYRIMIDINYL(METHVL)CARBAMATE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-02-16 | — | — | WO | claimed |
| CN-1845918-A | Pyrimidines useful as modulators of voltage-gated ion channels | VERTEX PHARMA (US) | 2006-10-11 | — | — | CN | claimed |
| CN-117466890-A | Preparation method of antithrombotic disease drug intermediate | 安徽美诺华药物化学有限公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2020164008-A1 | PROCESS FOR THE PREPARATION OF POROUS MICROPARTICLES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-20 | — | — | WO | disclosed |
| CN-110267949-A | SGC stimulant | 塞科里昂医疗股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| US-10414766-B2 | Polymorph of Riociguat and its process for the preparation | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2019-09-17 | — | — | US | disclosed |
| US-20190002461-A1 | NOVEL POLYMORPH OF RIOCIGUAT AND ITS PROCESS FOR THE PREPARATION | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2019-01-03 | — | — | US | disclosed |
| WO-2017107052-A1 | SOLUBLE GUANYLATE CYCLASE STIMULATORS | MERCK SHARP & DOHME CORP. (US) | 2017-06-29 | — | — | WO | disclosed |
| WO-2017025981-A1 | PROCESS FOR THE PREPARATION OF METHYL 4,6-DIAMINO-2-[L-(2-FHIOROBENZVR)-LH-PYRAZOLO I3,4-BLPVRIDIN-3-VN-5-PYRIMIDINYL(METHVL)CARBAMATE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-02-16 | — | — | WO | disclosed |
| US-20160106102-A1 | KNOWN AND NEW HETEROCYCLIC COMPOUNDS AS PEST CONTROL AGENTS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-04-21 | — | — | US | disclosed |
| EP-2802587-A2 | SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2014-11-19 | — | — | EP | disclosed |
| CN-100506825-C | Heterotricyclyl 6-alkylidene-penems as beta epsilontaualpha-lactamase inhibitors | WYETH CORP (US) | 2009-07-01 | — | — | CN | disclosed |
| CN-101189010-A | Tricyclic 6-alkylidene-penems as class D beta-lactamase inhibitors | WYETH CORP (US) | 2008-05-28 | — | — | CN | disclosed |
| CN-1845918-A | Pyrimidines useful as modulators of voltage-gated ion channels | VERTEX PHARMA (US) | 2006-10-11 | — | — | CN | disclosed |
| CN-1649882-A | Heterotricyclyl 6-alkylidene-penems as beta epsilontaualpha-lactamase inhibitors | WYETH CORP (US) | 2005-08-03 | — | — | CN | disclosed |
| EP-1102768-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES CONDENSED WITH SIX-MEMBERED HETEROCYCLIC RINGS | Bayer Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
| EP-1102767-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000066582-A1 | SUBSTITUTED PYRAZOLE DERIVATIVE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000006568-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006569-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES CONDENSED WITH SIX-MEMBERED HETEROCYCLIC RINGS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002461-A1 | NOVEL POLYMORPH OF RIOCIGUAT AND ITS PROCESS FOR THE PREPARATION | RIOK1, RIOK2, RIOK3 | ALDH1A1 1256/4885KMT2A 3182/4885MEN1 4510/4885 |
| US-10414766-B2 | Polymorph of Riociguat and its process for the preparation | RIOK2, RIOK1, RIOK3 | ALDH1A1 1176/4885KMT2A 3346/4885MEN1 4435/4885 |
| US-20160106102-A1 | KNOWN AND NEW HETEROCYCLIC COMPOUNDS AS PEST CONTROL AGENTS | DDT, ACHE, NISCH | ALDH1A1 2634/4885KMT2A 831/4885MEN1 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.