Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472222 | 0.90 | NPC1 (0.62) | EGFRNPC1CLK4DYRK1ALMNA | |
| SCHEMBL7474181 | 0.83 | MAPK1 (0.56) | EGFRNPC1LMNAMAPTMAPK1 | |
| SCHEMBL7528662 | 0.82 | EGFR (0.52) | EGFRNPC1LMNAMAPTMAPK1 | |
| SCHEMBL7469700 | 0.82 | EGFR (0.54) | EGFRCLK4LMNAMAPTMAPK1 | |
| SCHEMBL7476281 | 0.81 | HRH4 (0.51) | NPC1CLK4DYRK1ALMNAMAPT | |
| SCHEMBL7469664 | 0.81 | HTT (0.63) | EGFRMAPTMAPK1HTTMEN1 | |
| SCHEMBL7462496 | 0.81 | WDR5 (0.40) | EGFRNPC1CLK4DYRK1ALMNA | |
| SCHEMBL7461530 | 0.80 | PKM (0.56) | EGFRNPC1LMNAMAPTMAPK1 | |
| SCHEMBL7462734 | 0.80 | EGFR (0.55) | EGFRLMNAMAPTMAPK1HTT | |
| SCHEMBL7469795 | 0.80 | EGFR (0.60) | EGFRLMNAMAPK1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |