Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 8/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 8/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169995 | 0.79 | PKM (0.70) | PKMSMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7462265 | 0.76 | CTSL (0.56) | SMN1; SMN2HTTKMT2ACTSLLMNA | |
| SCHEMBL10618623 | 0.76 | PKM (0.45) | PKMSMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL1006670 | 0.72 | ALDH1A1 (0.50) | SMN1; SMN2RECQLKMT2ALMNATDP1 | |
| SCHEMBL1006669 | 0.72 | ALDH1A1 (0.50) | SMN1; SMN2RECQLKMT2ALMNATDP1 | |
| SCHEMBL1607014 | 0.72 | CTSB (0.56) | SMN1; SMN2HTTKMT2ACTSL | |
| SCHEMBL4178596 | 0.72 | PKM (0.64) | PKMSMN1; SMN2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL27482719 | 0.71 | NR1H4 (0.46) | SMN1; SMN2TAS1R3TAS1R1HTTKMT2A | |
| SCHEMBL27515259 | 0.70 | MAOA (0.47) | TP53KMT2ATSHRLMNAMAPK1 | |
| SCHEMBL4166794 | 0.69 | PKM (1.00) | PKMSMN1; SMN2TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983228-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | claimed |
| US-20020065230-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-05-30 | — | — | US | claimed |
| EP-0983228-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | claimed |
| WO-1998050342-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | claimed |
| EP-0983228-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| US-20020065230-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-05-30 | — | — | US | disclosed |
| EP-0983228-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050342-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065230-A1 | Protease inhibitors | PRSS1, DNPEP, CTSZ | PKM 3629/4885SMN1; SMN2 4738/4885TAS1R3 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.